1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Cytochrome P450

Cytochrome P450

P450

CYPs

Cytochrome p450 comprises a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in every class of organism, including Archaea, the p450 superfamily is believed to have originated from an ancestral gene that existed over 3 billion years ago. Repeated gene duplications have subsequently given rise to one of the largest of multigene families. These enzymes are notable both for the diversity of reactions that they catalyze and the range of chemically dissimilar substrates upon which they act. Cytochrome p450s support the oxidative, peroxidative and reductive metabolism of such endogenous and xenobiotic substrates as environmental pollutants, agrochemicals, plant allelochemicals, steroids, prostaglandins and fatty acids. In humans, Cytochrome p450s are best known for their central role in phase I drug metabolism where they are of critical importance to two of the most significant problems in clinical pharmacology: drug interactions and interindividual variability in drug metabolism.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-100386S
    Ticlopidine-d4
    Inhibitor
    Ticlopidine-d4 is the deuterium labeled Ticlopidine. Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC50 of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC50s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively[1]. Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC50s of 26.0 and 32.3 μM, respectively[2][3].
    Ticlopidine-d<sub>4</sub>
  • HY-P1089
    Cytochrome c-pigeon (88-104)
    Cytochrome c-pigeon (88-104) (PCC 88-104) has full stimulatory activity for pigeon cytochrome c-primed T cells from B10.A mice. The I-Ek-restricted T cell response to Cytochrome c pigeon (pcyt c) is specific for the COOH-terminal sequence 88-104.
    Cytochrome c-pigeon (88-104)
  • HY-13832S2
    Atovaquone-d5
    Inhibitor
    Atovaquone-d5 is the deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and  P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].
    Atovaquone-d<sub>5</sub>
  • HY-N0125S
    Diosmetin-d3
    Inhibitor
    Diosmetin-d3 is the deuterium labeled Diosmetin. Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC50 of 40 μM in HepG2 cell.
    Diosmetin-d<sub>3</sub>
  • HY-149770
    CYP4A11/CYP4F2-IN-2
    Inhibitor
    CYP4A11/CYP4F2-IN-2 (compound 15) is an orally available inhibitor of CYP4A11/4F2 with IC50s of 120 nM and 220 nM, respectively. CYP4A11/CYP4F2-IN-2 inhibits 20-HETE production in rat kidney and has potential inhibitory effects on diabetic nephropathy and autosomal dominant polycystic kidney disease.
    CYP4A11/CYP4F2-IN-2
  • HY-E70481
    Human CYP2A13,High-Reductase
    Human CYP2A13, High-Reductase, a recombinant CYP2A13, is a member of the CYP enzyme family and is expressed in human extrahepatic tissues.
    Human CYP2A13,High-Reductase
  • HY-E70491
    Human CYP3A5,High-Reductase
    Human CYP3A5, High-Reductase, a recombinant CYP3A5, is a member of the CYP enzyme family. CYP3A5 is mainly expressed in the prostate and the liver.
    Human CYP3A5,High-Reductase
  • HY-E70467
    Human CYP2D6,Low-Reductase
    Human CYP2D6, Low-Reductase a recombinant CYP2D6, is a member of the CYP enzyme family. CYP2D6 plays important roles in the liver and in the brain with regards to xenobiotic metabolism.
    Human CYP2D6,Low-Reductase
  • HY-B0365AS
    Memantine-d6 hydrochloride
    Inhibitor ≥98.0%
    Memantine-d6 (hydrochloride) is the deuterium labeled Memantine hydrochloride. Memantine (hydrochloride) (D-145 (hydrochloride)) is a moderate affinity, uncompetitive NMDA receptor antagonist, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively[1].
    Memantine-d<sub>6</sub> hydrochloride
  • HY-B1351
    Bilberry Extract
    Bilberry Extract is a bilberry extract, and its components include: Anthocyanidins. Bilberry Extract has potential antioxidant activity and can regulate specific metabolic enzymes in the liver, such as cytochrome P450 (CYP) 2C11 and CYP2E1 involved in drug metabolism..
    Bilberry Extract
  • HY-150580
    CYP3A4-IN-2
    Inhibitor
    CYP3A4-IN-2 is a specific inhibitor of cytochrome P450 3A4 (CYP3A4) with the IC50 value of 0.055 μM. CYP3A4-IN-2 is a ritonavir analogue with increased hydrophobicity of the R2 side group and stronger inhibitory effect compared to ritonavir. CYP3A4-IN-2 can be used as an antiviral agent and immunosuppressants.
    CYP3A4-IN-2
  • HY-N6023
    Thermopsoside
    Inhibitor
    Thermopsoside is a flavone derivative isolated from Aspalathus linearis. Thermopsoside exhibits inhibitory effects on CYP450 isozymes with IC50 values of 6.0 μM, 9.5 μM, 12.0 μM, 32.0 μM, for CYP3A4, CYP2C19, CYP2D6 and CYP2C9, respectively.
    Thermopsoside
  • HY-N0482R
    Phillyrin (Standard)
    Activator
    Phillyrin (Standard) is the analytical standard of Phillyrin. This product is intended for research and analytical applications. Phillyrin is isolated from Forsythia suspensa Vahl (Oleaceae), has antibacterial and anti-inflammatory activities. Phillyrin has potential inductive effects on rat CYP1A2 and CYP2D1 activities, without affecting CYP2C11 and CYP3A1/2 activities. Phillyrin has anti-influenza A virus activities.
    Phillyrin (Standard)
  • HY-B1751F
    Quinidine gluconic acid
    Inhibitor
    Quinate is an antiarrhythmic agent. Quinate is a potent, orally active, selective cytochrome P450db inhibitor. Quinate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinate can be used for malaria research.
    Quinidine gluconic acid
  • HY-B0852S
    Tebuconazole-d9
    Inhibitor
    Tebuconazole-d9 is the deuterium labeled Tebuconazole. Tebuconazole is an agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively.
    Tebuconazole-d<sub>9</sub>
  • HY-17459R
    Clopidogrel (hydrogen sulfate) (Standard)
    Inhibitor
    Clopidogrel (hydrogen sulfate) (Standard) is the analytical standard of Clopidogrel (hydrogen sulfate). This product is intended for research and analytical applications. Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC50s of 18.2 nM and 524 nM, respectively. Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation.Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor.
    Clopidogrel (hydrogen sulfate) (Standard)
  • HY-17508R
    Clarithromycin (Standard)
    Inhibitor
    Clarithromycin (Standard) is the analytical standard of Clarithromycin. This product is intended for research and analytical applications. Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC50 (Ki) value of 56 (43) μM. Clarithromycin significantly inhibits the HERG potassium current.Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K.
    Clarithromycin (Standard)
  • HY-133091S
    7-Ethoxycoumarin-d5
    7-Ethoxycoumarin-d5 is deuterium labeled 7-Ethoxycoumarin. 7-Ethoxycoumarin is a substrate for cytochrome P450(CYP450) and has been used in the functional characterization of various CYPs[1].
    7-Ethoxycoumarin-d<sub>5</sub>
  • HY-151140
    CYP11B1-IN-2
    Inhibitor
    CYP11B1-IN-2 (compound 7aa) is an orally active, potent and selective CYP11B1 inhibitor, with IC50 values of 9 nM and 25 nM for human CYP11B1 and rat CYP11B1, respectively. CYP11B1-IN-2 can be used for the research of diseases caused by excessive cortisol.
    CYP11B1-IN-2
  • HY-167737
    (-)-Vorozole
    Inhibitor
    (-)-Vorozole is an orally active non-steroidal aromatase inhibitor with potent and selective properties. (-)-Vorozole demonstrates antitumor activity in in vivo experiments. (-)-Vorozole is utilized in the study of breast cancer.
    (-)-Vorozole
Cat. No. Product Name / Synonyms Application Reactivity

CYP1

CYP2

CYP3

CYP4

CYP11

CYP17

Aromatase/CYP19A1

CYP26

CYP51

CYP1A2

CYP2D6

CYP2C9

CYP2C19

CYP3A4

CYP17A1

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Please try each isoform separately.

Cytochrome P450 Inducers, Degraders, Inhibitors, Activators & Modulators
Product NameCYP1CYP2CYP3CYP4CYP11CYP17Aromatase/CYP19A1CYP26CYP51CYP1A2CYP2D6CYP2C9CYP2C19CYP3A4CYP17A1Purity    
Verapamil  
CYP3
            99.96%
Fenofibrate 
CYP2C19, IC50: 0.2 μM
CYP2B6, IC50: 0.7 μM
CYP2C9, IC50: 9.7 μM
CYP2C8, IC50: 4.8 μM
CYP3A4, IC50: 142.1 μM
            99.97%
Apigenin 
CYP2
             99.22%
Verapamil hydrochloride  
CYP3
            99.98%
Aminoglutethimide      
Aromatase
        98.79%
Letrozole      
Aromatase
        99.95%
Ketoconazole  
CYP3
CYP4
           99.51%
Abiraterone     
CYP17
         99.88%
1-Aminobenzotriazole 
CYP2
CYP3
            99.88%
Abiraterone acetate     
CYP17
         99.96%
Clarithromycin  
CYP3
            99.90%
Stiripentol 
CYP2
CYP3
            99.99%
Cepharanthine 
CYP2E1, IC50: 25.62 μM
CYP2C9, IC50: 24.57 μM
CYP3A4, IC50: 16.29 μM
            99.91%
Diosmetin
CYP1
              99.63%
Gemfibrozil 1-O-β-glucuronide 
CYP2C8, IC50: 4.07 μM
             99.88%
Salvianolic acid C 
CYP2C8, Ki: 4.82 μM
CYP2J2, Ki: 5.75 μM
             99.94%
Fomepizole 
CYP2E1
             99.67%
Oleuropein      
Aromatase
        99.05%
Talarozole       
CYP26
       99.61%
HET0016   
CYP4
           99.69%
Anastrozole      
Aromatase
        99.99%
(S)-Mephenytoin 
CYP2
             99.85%
Galangin
CYP1
              99.96%
Sulfaphenazole 
CYP2C9
             99.85%
Cobicistat  
CYP3
            99.77%
Gemfibrozil
CYP1A2, Ki: 82 μM
CYP2C9, Ki: 5.8 μM
CYP2C19, Ki: 24 μM
CYP2C8, Ki: 69 μM
             99.91%
Troleandomycin  
CYP3
            ≥98.0%
Exemestane      
Aromatase
        99.83%
Clobetasol propionate  
CYP3A5, IC50: 0.206 μM
CYP3A4, IC50: 15.6 μM
            99.85%
Schisandrin A  
CYP3A, IC50: 6.6 μM
            99.89%
Clopidogrel hydrogen sulfate 
CYP2B6, IC50: 18.2 nM
CYP2C19, IC50: 524 nM
             99.43%
Bergamottin
CYP1A1, Ki: 10.703 nM
CYP1A1, IC50: 0.192 μM
CYP1A2, IC50: 5.077 μM
CYP2B2, IC50: 4.535 μM
CYP2B1, IC50: 9.495 μM
             99.80%
Isavuconazole  
CYP3
            99.99%
Ginsenoside C-K 
CYP2C9, IC50: 32 μM
CYP2A6, IC50: 63.6 μM
             99.92%
Gentiopicroside 
CYP2
             99.83%
TMS
CYP1B1, IC50: 6 nM
CYP1A1, IC50: 300 nM
CYP1A2, IC50: 3.1 μM
CYP1B1, Ki: 3 nM
              98.61%
Alpha-Naphthoflavone      
Aromatase
        98.54%
K777  
CYP3
            99.77%
Pregnenolone 16α-carbonitrile 
CYP2
CYP3
            98.48%
AS1810722  
CYP3A4
            98.14%
Ginsenoside Rd
CYP1A2, IC50: 78.4 μM
CYP2D6, IC50: 58 μM
CYP2C9, IC50: 85.1 μM
CYP3A4, IC50: 81.7 μM
            99.88%
Olivetol 
CYP2
             99.81%
Tetrahydrocurcumin 
CYP2C9
CYP3A4
            98.96%
7-Ethoxyresorufin
CYP1
              99.61%
Phillyrin
CYP1
CYP2
             98.99%
Topiroxostat  
CYP3
            99.06%
Rhapontigenin
CYP1A1, IC50: 400 nM
              99.66%
Atazanavir  
CYP3
            99.86%
Dronedarone  
CYP3
            99.93%
Clomethiazole 
CYP2
             98.65%
Galeterone     
CYP17
         99.87%
BMS-986202 
CYP2C19, IC50: 14 μM
             99.92%
Endoxifen hydrochloride      
Aromatase
        98.75%
Atazanavir sulfate  
CYP3
            99.94%
Ranitidine hydrochloride 
CYP2
             99.88%
Mephenytoin 
CYP2
             99.96%
CYP3cide  
CYP3A4, EC50: 30 nM
CYP3A5, EC50: 17 μM
CYP3A7, EC50: 71 μM
            99.92%
Curcumenol  
CYP3
            99.98%
Schisandrol B 
CYP2
CYP3A
            99.99%
Ticlopidine 
CYP2
CYP3
            99.56%
Tebuconazole        
CYP51
      99.66%
Bergaptol  
CYP3
            99.44%
5,7-Dimethoxyflavone  
CYP3A
            99.86%
Chlorzoxazone 
CYP2
             99.84%
Endoxifen      
Aromatase
        99.42%
Utreloxastat         
CYP1A2, IC50: > 5.3 μM
     99.69%
Fadrozole hydrochloride      
Aromatase
        99.91%
Oteseconazole           
CYP2C9, IC50: 99 μM
CYP2C19, IC50: 72 μM
  99.46%
Cecropin B  
CYP3
            99.00%
LKY-047 
CYP2J2, IC50: 1.7 μM
             99.94%
Dihydromethysticin  
CYP3
            99.94%
Casopitant mesylate  
CYP3A4
            99.84%
(S)-(+)-N-3-Benzylnirvanol            
CYP2C19, Ki: 250 nM
  99.82%
Cedrol 
CYP2
CYP3
            99.76%
APD668 
CYP2C9, Ki: 0.1 μM
             99.73%
Fadrozole      
Aromatase
        99.78%
Columbamine chloride             
CYP3A4, IC50: 30.6 μM
 98.63%
Obtusifoliol        
CYP51
      99.86%
Isosilybin  
CYP3
            99.95%
Harmalol hydrochloride
CYP1
              99.72%
Fipronil
CYP1
CYP2
CYP3
            98.98%
Oxiconazole nitrate  
CYP3A4
            ≥98.0%
Ginsenoside F1 
CYP2
CYP3A4
            ≥99.0%
AZD7325
CYP1A2
 
CYP3A4
            99.71%
Seviteronel     
CYP17
         99.83%
Cephaeline dihydrochloride 
CYP2
             99.84%
6',7'-Dihydroxybergamottin  
CYP3A4
            ≥99.0%
β-​Apo-​8'-​carotenal
CYP1A1
CYP1A2
              
Ranitidine 
CYP2C19
CYP2C9
             ≥99.0%
Liarozole       
CYP26, IC50: 7 μM
       98.83%
Friedelin 
CYP2
CYP3
            ≥99.0%
Flavanone      
Aromatase
        99.84%
Dihydrolanosterol        
CYP51
      99.56%
TP0472993   
CYP4A11, IC50: 140 nM
CYP4F2, IC50: 40 nM
           98.69%
Ezutromid
CYP1
              98.10%
PC945        
CYP51A, IC50: 0.23 μM
CYP51B, IC50: 0.22 μM
      99.27%
AMG-208  
CYP3A4, IC50: 32 μM
            99.86%
Tetrahydropiperine
CYP1A1, IC50: 23 μM
              99.41%
Nicotelline       
CYP26, Ki: ≥300 μM
       99.92%
MS-PPOH 
CYP2
             99.27%
Mefentrifluconazole        
CYP51A, Kd: 0.5 nM
      99.61%
2-Phenyl-2-(1-piperidinyl)propane
CYP1A2, IC50: >300 μM
CYP2B6, IC50: 5.1 μM
CYP2B6, Ki: 5.6 μM
CYP2D6, IC50: 74 μM
CYP2A6, IC50: >300 μM
CYP2C8, IC50: >300 μM
CYP2C9, EC50: >300 μM
CYP2C19, IC50: >300 μM
CYP2E1, IC50: >300 μM
CYP3A, IC50: 200 μM
            99.81%
Dagrocorat 
CYP2D6
CYP3A
            99.90%
(R)-(+)-Aminoglutethimide      
Aromatase
        
Columbamine             
CYP3A4, IC50: 30.6 μM
 99.70%
NN1177 TFA             
CYP3A4
 98.66%
Carbosulfan
CYP1
CYP2
CYP3
            ≥98.0%
Orteronel     
CYP17
         99.70%
Dapaconazole       
CYP26, IC50: 1.4 μM
       99.76%
Quilseconazole        
CYP51
      98.98%
N-Nornuciferine 
CYP2
             99.94%
Linderane 
CYP2
             99.61%
IDO1-IN-19 
CYP2C9, IC50: 8.64 μM
             98.52%
Chrysosplenetin  
CYP3A
            99.68%
Fenofibrate (Standard) 
CYP2B6
CYP2C19
CYP2C8
CYP2C9
CYP3A4
            99.91%
2,6-Dimethylquinoline
CYP1A2, IC50: 3.3 μM
CYP2B6, IC50: 480 μM
             99.95%
ACP-5862 
CYP2C8
CYP3A4
            98.41%
DMU2105
CYP1B1, IC50: 10 nM
CYP1A1, IC50: 742 nM
              99.54%
BI 689648    
CYP11
          99.20%
Nampt-IN-5  
CYP3, IC50: 0.7 nM
            98.02%
Phortress
CYP1
              99.25%
α-​Terpinyl acetate 
CYP2B6, Kd: 5.4  μM
             
ML252
CYP1A2, IC50: 6.1 μM
CYP2C9, IC50: 18.9 μM
CYP2D6, IC50: 19.9 μM
CYP3A4, IC50: 3.9 μM
            99.9%
CYP19A1-IN-2      
Aromatase
        98.88%
Antihistamine-1 
CYP2D6, IC50: 5.4 μM
             99.45%
D4-abiraterone     
CYP17
         99.75%
CYP1B1-IN-4
CYP1B1, IC50: 0.2 nM
CYP1A1, IC50: 3.98 μM
              99.09%
Liarozole dihydrochloride       
CYP26, IC50: 7 μM
       ≥99.0%
Polygalaxanthone III 
CYP2
             99.76%
ONT-993 
CYP2D6, IC50: 7.9 μM
             99.85%
BI 653048
CYP1A2, IC50: 50 μM
CYP2D6, IC50: 41 μM
CYP2C9, IC50: 12 μM
CYP2C19, IC50: 9 μM
CYP3A4, IC50: 8 μM
            99.84%
DMU2139
CYP1B1, IC50: 9 nM
CYP1A1, IC50: 795 nM
              ≥98.0%
Fomepizole hydrochloride 
CYP2E1
             99.85%
Pradefovir mesylate  
CYP3
            99.89%
Exemestane (Standard)      
Aromatase
        99.63%
Abiraterone acetate (Standard)     
CYP17
         99.85%
8-Geranyloxypsoralen  
CYP3
            99.93%
SDZ285428        
CYP51
      98.00%
Dagrocorat hydrochloride 
CYP2D6
CYP3A
            99.85%
CYP4A11/CYP4F2-IN-1   
CYP4A11, IC50: 19 nM
CYP4F2, IC50: 17 nM
           99.82%
SR9186  
CYP3
            98.06%
Seviteronel (R enantiomer)     
CYP17
         98.82%
Letrozole-d4      
Aromatase
        99.82%
Abiraterone decanoate     
CYP17
         99.69%
BMS-819881  
CYP3A4, EC50: 13 μM
            
hCYP3A4 Fluorogenic substrate 1  
CYP3A4, Km: 0.36 μM
            99.27%
MCH-1 antagonist 1  
CYP3A4, IC50: 10 μM
            
1'-Hydroxy bufuralol 
CYP2
             
Eriodictyol chalcone      
Aromatase
        
ε-​Viniferin
CYP1A2, Ki: 5 μM ((EROD))
CYP2B6, Ki: 3 μM ((BROD))
CYP2A6, Ki: 60 μM ((COH))
CYP2E1, IC50: 25 μM ((CHZ))
CYP3A4, Ki: 10 μM ((TST))
CYP4A, IC50: 15 μM ((LwOH))
           ≥98.0%
Gemfibrozil (Standard)
CYP1A2
CYP2C19
CYP2C8
CYP2C9
             99.90%
CYP11B2-IN-1    
CYP11B2, IC50: 2.3 nM
CYP11B1, IC50: 142 nM
          99.83%
Revexepride  
CYP3A4
            99.84%
1-(Isothiazol-3-yl)ethan-1-one 
CYP2E1
             
Tabimorelin  
CYP3A4
            
Azamulin  
CYP3A, IC50: 0.03-0.24 μM
            
Resorufin methyl ether
CYP1
              99.75%
Chlorzoxazone (Standard) 
CYP2
             99.81%
4,5-Dimethoxycanthin-6-one
CYP1A2, IC50: 1.7 μM
CYP1A2, Ki: 2.6 μM
              98.68%
Vorozole      
Aromatase
        
ODM-204     
CYP17
         
IHMT-PI3Kδ-372 
CYP2C9, IC50: 2.7 μM
             
BMS-986339 
CYP2C8, IC50: 8 μM
CYP2C9, IC50: 13.5 μM
             
Fadrozole hydrochloride hemihydrate      
Aromatase
        
Anastrozole-d12      
Aromatase
        
Endoxifen-d5      
Aromatase
        
CYP3A4-IN-2  
CYP3A4, IC50: 0.055 μM
            
Clarithromycin (Standard)  
CYP3
            
CYP11B1-IN-2
CYP1A2, IC50: >10 μM
CYP2C9, IC50: >10 μM
CYP2C19, IC50: >10 μM
CYP2D6, IC50: >10 μM
CYP2E1, IC50: >10 μM
CYP3A4, IC50: >10 μM
 
CYP11B1, IC50: 9 ± 2 nM (human CYP11B1)
CYP11B1, IC50: 25 nM (rat CYP11B1)
CYP11B2, IC50: 1121 ± 237 nM
          
Antitumor agent-88
CYP1A1, Ki: 1.4 μM
              
17-HETE
CYP1B1
              
SYN20028567      
Aromatase
        
P-gp inhibitor 23             
CYP3A4
 
CYP4Z1-IN-1 
CYP2D6, IC50: >10 000 nM
CYP2C9, IC50: >10 000 nM
CYP3A4, IC50: >10 000 nM
CYP4Z1, IC50: 41.8 ± 1.4 nM
CYP4F11, IC50: 291.3 ± 46 nM
CYP4F12, IC50: 1598.3 ± 5 nM
           
CYP3A4-IN-3  
CYP3A4, IC50: 0.075 μM
            
Diosmetin (Standard)
CYP1
              
CYP1B1-IN-2
CYP1B1, IC50: 0.52 nM
CYP1A1, IC50: 16.7 nM
CYP1A2, IC50: 94.2 nM
              
ERα degrader 9      
Aromatase
        
Ginsenoside C-K (Standard) 
CYP2A6
CYP2C9
             
CYP17-IN-1     
CYP17
         
FGFRs-IN-1         
CYP1A2, IC50: 26.33 μM
CYP2D6, IC50: 9.27 μM
 
CYP2C19, IC50: 11.46 μM
  
CYP1B1-IN-5
CYP1B1, IC50: 4.7 nM
CYP1A1, IC50: 190.7 nM
CYP1A2, IC50: 585.7 nM
              
FGFR-IN-10 
CYP2C9, IC50: 3.33 μM
CYP2C19, IC50: 18.75 μM
CYP2D6, IC50: 4.34 μM
CYP3A4, IC50: 0.69 μM
            
CYP17A1/HDAC6-IN-1              
CYP17A1, IC50: 0.284 μM
hCYP1B1-IN-2
CYP1B1, IC50: 0.040 nM
CYP1A1, IC50: 0.38 nM
              
Ginsenoside Rd (Standard)
CYP1A2
CYP2C9
CYP2D6
CYP3A4
            
Antiproliferative agent-53-d3 
CYP2C19, IC50: 0.77 μM
CYP2C9, IC50: 3.1 μM
CYP2D6, IC50: 17.3 μM
CYP3A4, IC50: 14.6 μM
            
CYP17A1-IN-1     
CYP17, IC50: 26 nM
         
HIV-1 inhibitor-40 
CYP2C9, IC50: 5.16 μM
CYP2C19, IC50: 4.51 μM
             
BChE-IN-33 
CYP2C19
CYP2C9
CYP2D6
             
ASN-001              
CYP17A1
Anticancer agent 78      
Aromatase
        
CYP3A4-IN-1  
CYP3A4, IC50: 0.085 μM
            
CYP51/HDAC-IN-1        
CYP51
      
Exemestane-13C3      
Aromatase
        
Kushenol K  
CYP3A4, Ki: 1.35 μM
            
N-Desmethyl diltiazem hydrochloride  
CYP3A7
            
EGFR-IN-137      
Aromatase, IC50: 4.01 μM
        
PROTAC ERα Degrader-9      
Aromatase, IC50: 4.6 μM
        
CYP1B1-IN-3
CYP1B1, IC50: 6.6 nM
CYP1A1, IC50: 347.3 nM
CYP1A2, IC50: >10000 nM
              
Antitumor agent-87
CYP1A1, Ki: 0.23 μM
              
DL-Acetylshikonin
CYP1A2, IC50: 4.0 μM
CYP2A6, IC50: 3.8 μM
CYP2B6, IC50: 2.0 μM
CYP2C8, IC50: 1.4 μM
CYP2C9, IC50: 3.3 μM
CYP2C19, IC50: 2.5 μM
CYP2D6, IC50: 2.5 μM
CYP2E1, IC50: 2.7 μM
CYP2J2, IC50: 3.3 μM
CYP3A, IC50: 2.3 μM
            
Exemestane-d2      
Aromatase
        
5,7,2',6'-Tetrahydroxyflavone  
CYP3A4, IC50: 7.8 μM
            
7-Ethoxy-4-methylcoumarin
CYP1A1
CYP2B6
CYP2B4
             99.44%
Aromatase-IN-3      
Aromatase, IC50: 54 nM
        
YM511      
Aromatase
        99.73%
BI 653048 phosphate
CYP1A2, IC50: 50 μM
CYP2D6, IC50: 41 μM
CYP2C9, IC50: 12 μM
CYP2C19, IC50: 9 μM
CYP3A4, IC50: 8 μM
            
Exemestane-d3      
Aromatase
        
Apigenin (Standard) 
CYP2
             
CFG920    
CYP11B2
CYP17
         
Nav1.7-IN-8 
CYP2C9, IC50: 0.17 μM
CYP3A4, IC50: 0.077 μM
            
Galangin (Standard)
CYP1
              
JNK-IN-14          
CYP2D6, IC50: 26.7 ± 0.5 nM
  
CYP3A4, IC50: 383.0 ± 1. nM
 
Clopidogrel-β-D-glucuronide 
CYP2C8
             
Bucolome 
CYP2
             98.93%
Fenofibrate-d6 
CYP2
CYP3
            99.70%
Oxiconazole  
CYP3A4
            
Tetrahydrocurcumin-d6 
CYP2
CYP3
            
Antibacterial agent 132      
Aromatase
        
1,2,3,6,7,8-Hexachlorodibenzofuran
CYP1A1
              
Androsta-1,4,6-triene-3,17-dione      
Aromatase
        
7-Hydroxyflavanone      
Aromatase
        99.59%
Phortress free base
CYP1
              
PROTAC CYP1B1 degrader-2
CYP1B1, DC50: 1 nM
              
hCYP3A4-IN-1  
CYP3A4, IC50: 43.93 nM
            
Monoamine oxidase/Aromatase-IN-1      
Aromatase
        
RO6889678  
CYP3A4
            
CYP51/PD-L1-IN-4        
CYP51, IC50: 0.17 ± 0.0 μM
      
Tabimorelin hemifumarate  
CYP3A4
            
Aromatase-IN-2      
Aromatase
        99.83%
17(S)-HETE
CYP1B1
              
Licopyranocoumarin  
CYP3A4, IC50: 32 μM
            
Methysticin
CYP1A1
              
Thujopsene 
CYP2B6, IC50: 1.3 μM
CYP2C19, IC50: 13.6 μM
CYP2C8, IC50: 29.8 μM
CYP2C9, IC50: 44.9 μM
CYP3A4, IC50: 12.6 μM
            
CYP11B2-IN-2    
CYP11B2, IC50: 0.3 nM
CYP11B1, IC50: 3.8 nM
          
10-Hydroxywarfarin           
CYP2C9, IC50: 1.6 μM
   
Isolimonexic acid      
Aromatase
        
CYP1B1 ligand 3
CYP1B1, IC50: 11.9 nM
CYP1A1, IC50: 278.7 nM
CYP1A2, IC50: 3913.5 nM
              
CYP3A4-IN-4  
CYP3A4
            
Cloperidone           
CYP2C9, IC50: 17.7 μM
   
CYP51/Hsp90-IN-1        
CYP51
      
CYP4Z1-IN-2   
CYP4Z1, Ki: 2.2 μM
           
ML252 hydrochloride
CYP1A2, IC50: 6.1 μM
CYP2C9, IC50: 18.9 μM
CYP2D6, IC50: 19.9 μM
CYP3A4, IC50: 3.9 μM
            
Sorafenib N-oxide             
CYP3A4, Ki: 15 μM
 
Org30958      
Aromatase